RESULTS: Comparison of the Q-Tc intervals before, 7 days, and 14 days after the initiation of azithromycin treatment revealed a mild, but not significant prolongation (median values 406, 412.5 and 419 ms with ranges of 339-488, 352-510, and 346-505 ms, respectively). Q-T intervals were measured manually in a blinded manner and corrected for heart rate according to Bazzet's formula: Q-Tc = measured Q-T (ms)/square root of R-R (s). Thus, a total of 141 ECG tracings were analyzed. In all of them ECGs were performed before as well as 7 and 14 days after initiation of the azithromycin therapy. The patients were previously healthy and were not receiving any other medication. METHODS: A prospective study was performed on 47 patients, 31 females and 16 males, aged 19-77 (median 52) years, treated with azithromycin (total dosage 3 g, divided over 5 days) for typical solitary erythema migrans. We opted to study the influence of the azalide antibiotic azithromycin on the duration of Q-Tc interval as data on this subject are limited. It may occur as an adverse effect of various pharmacological agents including macrolides. Prolongation of the corrected Q-T (Q-Tc) interval is associated with a risk of severe and even life-threatening arrythmias. Is azithromycin treatment associated with prolongation of the Q-Tc interval?ĭepartment of Infectious Diseases, University Medical Centre Ljubljana, Slovenia.
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